Gellan gum-based hydrogels for intervertebral disc tissue-engineering applications
نویسندگان
چکیده
منابع مشابه
Gellan gum: a new biomaterial for cartilage tissue engineering applications.
Gellan gum is a polysaccharide manufactured by microbial fermentation of the Sphingomonas paucimobilis microorganism, being commonly used in the food and pharmaceutical industry. It can be dissolved in water, and when heated and mixed with mono or divalent cations, forms a gel upon lowering the temperature under mild conditions. In this work, gellan gum hydrogels were analyzed as cells supports...
متن کاملDevelopment of gellan gum-based microparticles/hydrogel matrices for application in the intervertebral disc regeneration.
Low back pain is one of the most reported medical conditions associated to intervertebral disc (IVD) degeneration. Nucleus pulposus (NP) is often regarded as the structure where IVD degeneration begins. Gellan gum (GG)-based hydrogels for acellular and cellular tissue engineering strategies have been developed for finding applications as NP substitutes. The innovative strategy is based on the r...
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Damage of non-vascularised tissues such as cartilage and cornea can result in healing processes accompanied by a non-physiological angiogenesis. Peptidic aptamers have recently been reported to block the vascular endothelial growth factor (VEGF). However, the therapeutic applications of these aptamers are limited due to their short half-life in vivo. In this work, an enhanced stability and bioa...
متن کاملGellan gum injectable hydrogels for cartilage tissue engineering applications: in vitro studies and preliminary in vivo evaluation.
Gellan gum is a polysaccharide that we have previously proposed for applications in the cartilage tissue engineering field. In this work, gellan gum hydrogels were tested for their ability to be used as injectable systems using simple processing methods, able to deliver and maintain chondrocytes by in situ gelation, and support cell viability and production of extracellular matrix (ECM). Rheolo...
متن کاملElectrically conducting PEDOT:PSS - gellan gum hydrogels
Hydrogels consisting of the conducting polymer PEDOT:PSS and the biopolymer gellan gum (GG) were characterized using electrical, mechanical and rheological methods. Compression testing and rheological analysis showed that the gels weakened with increasing PEDOT:PSS content. In contrast, the increasing PEDOT:PSS content resulted in an increasing electrical conductivity. Disciplines Medicine and ...
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ژورنال
عنوان ژورنال: Journal of Tissue Engineering and Regenerative Medicine
سال: 2010
ISSN: 1932-6254
DOI: 10.1002/term.363